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The generally sporadic occurrence of Wolff-Parkinson-White (WPW) syndrome or supraventricular tachycardia (SVT) due to an accessory atrioventricular pathway does not suggest an obvious genetic basis, but several lines of evidence suggest that genetic mutations play a role in the development of this abnormality.

The cause of Parkinson's cases remains unclear. Approximately 15 percent of people with Parkinson disease have a family history of this disorder. Familial cases of Parkinson disease can be caused by mutations in the LRRK2, PARK7, PINK1, PRKN, or SNCA gene, or by alterations in genes that have not been identified.

Monogenetic disorders are caused by a mutation in a single gene. The mutationmay be present on one or both chromosomes, one chromosome inherited from each parent. Examples of monogenic disorders are: sickle cell disease, cystic fibrosis, polycystic kidney disease, and Tay-Sachs disease.

A genetic disorder is a condition that is caused by an abnormality in an individual's DNA. Abnormalities can be as small as a single-base mutation in just one gene, or they can involve the addition or subtraction of entire chromosomes. Find out how single gene disorders can be inherited.

In this instance, a specific gene from one or both parents leads to an abnormality.Examples of such a condition would be sickle cell anemia, cystic fibrosis, or hemophilia. These illnesses are inherited, a direct result from the parents' genetic make-up, and therefore are sometimes referred to as hereditary diseases.

There are three types of genetic disorders: 1) Single-gene disorders, where a mutation affects one gene. Sickle cell anemia is an example. 2) Chromosomal disorders, where chromosomes (or parts of chromosomes) are missing or changed. 3) Complex disorders, where there are mutations in two or more genes.