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The immune system is involved, but not exactly like an autoimmune disease. Because it affects the connective tissues, it is a rheumatic disease, but because there is not yet an effective remedy, treated as a procedure disease. Treatment is for correction of deformity from Dupuytren contracture.

Dupuytren's contracture, also known as Dupuytren's disease, is a hand deformity that causes the tissue beneath the surface of the hand to thicken and contract. Evidence of Dupuytren's usually begins with a thickening of the palm.

Lumps occur on the palm in the initial phase of this disease. During the first stage of Dupuytrens disease, lumps are sore and tender. The presence of nodules that leads to a knotty growth of tissues causes the curling of fingers. At times, these jerks worsen in intensity, leading to difficulties in bringing back the finger to the normal position.

Dupuytren contracture is a common hereditary disorder that occurs particularly in men, especially after age 45. However, having the abnormal gene does not guarantee that someone will have the disorder.  Dupuytren contracture is more common among people with diabetes, or epilepsy.

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After one week, return to activities as tolerated. Occasionally a splint is prescribed for night use. After a partial palmar fasciectomy, physical or occupational therapy sessions will be needed for up to six weeks.